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DNA region linked to disease resistance in tilapia

A section of the genetic code significantly affects survival during a virus outbreak, leading to the potential for breeding resistant fish.

DNA region linked to disease resistance in tilapia
Scientists analyzed the genome of almost 1,000 fish from a pond that had experienced an outbreak of Tilapia Lake Virus. Credits: Mahirah Mahmuddin, WorldFish

July 15, 2021


A specific region in the genome of Nile tilapia has a major effect on mortality levels during an outbreak of Tilapia Lake Virus (TiLV), a study led by the Roslin Institute and WorldFish has found. Fish with specific genetic variants in this region were substantially less likely to die in an outbreak of the virus than fish without these variants. Survival rates improved by approximately one-third, scientists observed.

By selecting parent fish for breeding based on these variants, tilapia strains with innate resistance can be developed. This will reduce the number of outbreaks and mortality rate of TiLV, which is one of the biggest threats to tilapia aquaculture, with mortalities up to 90% and for which vaccines are not yet available.

Scientists analyzed the genome of almost 1,000 fish from a pond that had experienced an outbreak of TiLV. Comparing the genomes of fish that survived the outbreak with fish that did not enable scientists to find the region in the genome containing variants associated with survival. The average survival rate of tilapia with the favorable variants was 32% higher than that of fish with none of the variants, scientists found.

“Tilapia Lake Virus can cause mass mortality to farmed Nile tilapia, which has major negative impacts on farmers and food security in many countries. Our results provide a clear route to selecting fish with improved genetic resistance to TiLV, with major potential to help tackle this devastating virus,” said Professor Ross Houston, Personal Chair of Aquaculture Genetics, Roslin Institute.

Breeders will be able to select the best candidates for resistance to Tilapia Lake Virus by marker-assisted selection, generating new strains of Nile tilapia with enhanced resistance. Interestingly, we also showed that this selection won’t have any negative impact on the fish harvest weight,” said Agustín Barria, Roslin Institute.

“This information will be invaluable in creating resilient tilapia breeds that can help maintain production of fish in the face of increasing disease risks that threaten food security in many parts of the world. WorldFish plans to incorporate TiLV resistance in the new strains of Genetically Improved Farmed Tilapia (GIFT) we are developing,” said Professor John Benzie, WorldFish.

The study was funded by the CGIAR Research Program on Fish Agri-Food Systems (FISH) and the Biotechnology and Biological Sciences Research Council, part of UK Research and Innovation. Check the study here.

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