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Study aims to produce lice-resistant salmon

Wednesday, March 9, 2022

UK scientists aim to identify genes that could make Atlantic salmon resistant to sea lice. Researchers aim to pinpoint key genes and associated biological processes underlying genetic resistance to these parasites.

This will include studying the response to lice attachment exhibited by coho salmon, a species of salmon which is fully resistant to sea lice, and then applying knowledge gained concerning mechanisms of resistance to Atlantic salmon, which is susceptible. 

The project is led by researchers from the Roslin Institute and the University of Stirling’s Institute of Aquaculture and will receive a total of £1.7 million from the Biotechnology and Biological Sciences Research Council (BBSRC) and the Sustainable Aquaculture Innovation Centre (SAIC). It is an industrial partnership award with aquaculture breeding company Benchmark Genetics.

Shortlisting genes

Researchers will use data previously collected from 12,000 infected fish to identify regions of the salmon genome associated with resistance to sea lice. They will also compare Atlantic salmon with coho salmon to investigate the key mechanisms, genes and proteins involved in their different responses to lice.

Gene-editing will be used to validate and shortlist genes and processes that could be linked to resistance, through tests examining the effects of silencing genes of interest. Initial research will be conducted in fish cells, to identify the genes that are most likely to be involved in resisting infection by lice. These genes will then be targeted to produce gene-edited salmon embryos.

Gene editing, which enables targeted, precise changes to the genetic code, has been used in previous studies by scientists from the Roslin Institute to identify disease resistance genes in salmon and has potential applications in aquaculture breeding to improve health and welfare traits.

Alternative control strategies, such as feed supplements, cleaner fish, and tailored cage design, are only partially effective and some lice are developing resistance to drugs. Selective breeding to increase resistance of salmon to lice is an effective but relatively slow process because a generation of salmon takes up to four years to reach maturity for reproduction.

“Different species show varying resistance to sea lice – while Atlantic salmon is highly susceptible, coho salmon is almost completely resistant. We are going to compare the genomes of the two species to understand how they are linked to their response to lice so that we can identify the key mechanisms underlying resistance in coho salmon. We can then attempt to transfer these resistance mechanisms from coho salmon to Atlantic salmon via genome editing,” said Diego Robledo from the Roslin Institute.

 

Photo credit: Landcatch Natural Selection Ltd.

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